Lab-grown male gonads set to revolutionise fertility research at Bar-Ilan University


Creation of laboratory-grown testicle organoids by scientists at Bar-Ilan University represents monumental achievement in reproductive medicine

A fluorescent image of a testicular organoid created from mouse embryos and incubated in a dish for 14 days.—SWNS

Scientists at Bar-Ilan University, led by Dr. Nitzan Gonen, have successfully created laboratory-grown testicle organoids, signifying a major stride in male fertility research, Interesting Engineering reported.

The innovative approach, detailed in the International Journal of Biological Sciences, showcases the potential to transform reproductive medicine.

The significance of the testis in male reproductive health cannot be overstated, being responsible for sperm production and testosterone synthesis. 

Dr Gonen’s team addressed the challenge of the lack of in vitro models for studying testis development by meticulously cultivating artificial testicles using cells derived from neonatal mice.

These miniature replicas closely imitate the natural structure and function of testes, providing researchers with a valuable tool for investigating the intricacies of testis development and function. Despite not yet producing mature sperm cells, the organoids displayed impressive longevity in vitro, lasting up to nine weeks.

Dr Gonen emphasises the far-reaching implications of this research, particularly in advancing therapeutic interventions for sexual development disorders and male infertility. The next phase involves refining the technique using human samples, aiming to translate these findings into clinical practice.

Looking forward, the researchers aim to utilise human samples to enhance the applicability of their work, potentially aiding fertility preservation in individuals undergoing cancer treatment. 

The creation of laboratory-grown testicle organoids represents a monumental achievement in reproductive medicine, offering unparalleled opportunities for unravelling the mysteries of testis development.

As the research progresses, the potential applications of testicle organoid production in areas such as fertility preservation and personalised treatment strategies are generating anticipation. 

With ongoing efforts to optimise the technique, reproductive medicine is on the verge of transformative breakthroughs in understanding and addressing male reproductive health.



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